偏身投掷症：脑脊液变化

Hemiballismus: changes in cerebrospinal fluid.

作者信息

Kostic V, Djuricic B, Paschen W

机构信息

Department of Neurology, School of Medicine, Belgrade, Yugoslavia.

出版信息

Acta Neurol Scand. 1988 Aug;78(2):115-7. doi: 10.1111/j.1600-0404.1988.tb03631.x.

DOI:10.1111/j.1600-0404.1988.tb03631.x

PMID:2459894

Abstract

Concentrations of serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA), and dopamine metabolites, homovanillic acid (HVA) and 3,4-dihydroxy-phenylacetic acid (DOPAC), were measured in the samples of cerebrospinal fluid of 5 patients with acute hemiballismus. The only significant change was the increased content of HVA compared to controls. This finding support the hypothesis on the increased dopamine turnover in hemiballismus and provide a rational basis for the present treatment with antidopaminergic agents.

摘要

在5例急性偏侧投掷症患者的脑脊液样本中，检测了血清素代谢物5-羟吲哚乙酸（5-HIAA）以及多巴胺代谢物高香草酸（HVA）和3,4-二羟基苯乙酸（DOPAC）的浓度。唯一显著的变化是与对照组相比，HVA含量增加。这一发现支持了偏侧投掷症中多巴胺周转率增加的假说，并为目前使用抗多巴胺能药物的治疗提供了合理依据。