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Transforming growth factor beta in the control of epidermal proliferation.

作者信息

Barnard J A, Bascom C C, Lyons R M, Sipes N J, Moses H L

机构信息

Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232.

出版信息

Am J Med Sci. 1988 Sep;296(3):159-63. doi: 10.1097/00000441-198809000-00003.

DOI:10.1097/00000441-198809000-00003
PMID:2459967
Abstract

Transforming growth factor beta is a polypeptide growth factor with a multiplicity of diverse biologic effects. Increasingly, data support a role for TGF beta in the autocrine regulation of normal epithelial cell growth (Figure 1). Definition of the normal pathways for growth stimulation and inhibition of epithelial cell growth by autocrine peptides like TGF beta and TGF alpha undoubtedly will increase understanding of normal growth and development, embryogenesis, wound repair, and tumorigenesis.

摘要

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