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臭氧疗法对干性年龄相关性黄斑变性的视力改善作用;综述

Visual improvement following ozonetherapy in dry age related macular degeneration; a review.

作者信息

Borrelli Emma, Bocci Velio

机构信息

Department of Biotechnologies, University of Siena, Italy.

Department of Physiology, University of Siena, Italy.

出版信息

Med Hypothesis Discov Innov Ophthalmol. 2013 Summer;2(2):47-51.

PMID:24600642
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3939750/
Abstract

The dry form of ARMD is becoming a serious problem because of the rise in the number of old individuals. No effective therapy is available in dry ARMD except for the illusory oral administration of antioxidant vitamins. Despite scepticism in the medical community, the therapeutic effect of ozonetherapy had been evaluated since 1996. This evaluation has been based on specific biochemical, molecular and pharmacological reactions. Nevertheless a number of visual scientists continue to ignore ozonetherapy conservatively and prescribe only antioxidant vitamins. Two small clinical studies involving 217 patients have been performed at the University of Siena showing that ozonetherapy can stop the progression of the disease while improving the visual acuity and the well-being of the patient. Moreover, it seems that ozonetherapy is a safe procedure and tends to have an excellent compliance.

摘要

由于老年人口数量的增加,干性年龄相关性黄斑变性(ARMD)正成为一个严重的问题。除了虚幻的口服抗氧化维生素外,干性ARMD没有有效的治疗方法。尽管医学界持怀疑态度,但自1996年以来一直在评估臭氧疗法的治疗效果。这种评估是基于特定的生化、分子和药理反应。然而,许多视觉科学家仍然保守地忽视臭氧疗法,只开抗氧化维生素。锡耶纳大学进行了两项涉及217名患者的小型临床研究,结果表明臭氧疗法可以阻止疾病的进展,同时提高患者的视力和健康状况。此外,臭氧疗法似乎是一种安全的治疗方法,而且患者的依从性往往很好。

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本文引用的文献

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Effects of major ozonated autohemotherapy in the treatment of dry age related macular degeneration: a randomized controlled clinical study.大剂量臭氧自血疗法治疗干性年龄相关性黄斑变性的疗效:一项随机对照临床研究。
Int J Ophthalmol. 2012;5(6):708-13. doi: 10.3980/j.issn.2222-3959.2012.06.11. Epub 2012 Dec 18.
2
NRF2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells.NRF2 激活参与了臭氧处理人血清中内皮细胞 HO-1 的上调。
Toxicol Appl Pharmacol. 2013 Feb 15;267(1):30-40. doi: 10.1016/j.taap.2012.12.001. Epub 2012 Dec 16.
3
How a calculated oxidative stress can yield multiple therapeutic effects.如何计算氧化应激以产生多种治疗效果。
Free Radic Res. 2012 Sep;46(9):1068-75. doi: 10.3109/10715762.2012.693609. Epub 2012 May 28.
4
Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress?臭氧疗法的作用机制:愈合是通过轻度氧化应激诱导的吗?
Med Gas Res. 2011 Dec 20;1:29. doi: 10.1186/2045-9912-1-29.
5
Ozone acting on human blood yields a hormetic dose-response relationship.臭氧作用于人体血液会产生一种适应原剂量反应关系。
J Transl Med. 2011 May 17;9:66. doi: 10.1186/1479-5876-9-66.
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The Nrf2 system as a potential target for the development of indirect antioxidants.Nrf2 系统作为间接抗氧化剂开发的潜在靶点。
Molecules. 2010 Oct 20;15(10):7266-91. doi: 10.3390/molecules15107266.
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