West Emily S, Williams Victoria L, Morelli Joseph G
Columbia University College of Physicians and Surgeons, New York, New York.
Pediatr Dermatol. 2015 Jan-Feb;32(1):153-4. doi: 10.1111/pde.12316. Epub 2014 Mar 6.
Neutrophilic panniculitis is a rare adverse effect of therapy with selective BRAF inhibitors. We report a case of neutrophilic panniculitis in a 15-year-old girl receiving treatment with vemurafenib for a brainstem glioma. Clinicians should be aware of this rare but important side effect of vemurafenib. This is the first report of neutrophilic panniculitis in a child treated with vemurafenib.
嗜中性脂膜炎是选择性BRAF抑制剂治疗罕见的不良反应。我们报告了一例15岁女孩接受维莫非尼治疗脑干胶质瘤时发生嗜中性脂膜炎的病例。临床医生应意识到维莫非尼这种罕见但重要的副作用。这是维莫非尼治疗儿童发生嗜中性脂膜炎的首例报告。
