细胞周期蛋白依赖性激酶在 T 细胞生物学中的新作用：连接细胞分裂与分化。
New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation.
机构信息
Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, USA; and The Children's Hospital of Philadelphia Research Institute, Abramson Research Center, 3615 Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA.
出版信息
Nat Rev Immunol. 2014 Apr;14(4):261-70. doi: 10.1038/nri3625. Epub 2014 Mar 7.
Abstract
The proliferation of a few antigen-reactive lymphocytes into a large population of effector cells is a fundamental property of adaptive immunity. The cell division that fuels this process is driven by signals from antigen, co-stimulatory molecules and growth factor receptors, and is controlled by the cyclin-dependent kinase (CDK) cascade. In this Opinion article, we discuss how the CDK cascade provides one potential link between cell division and differentiation through the phosphorylation of immunologically relevant transcription factors, and how components of this pathway might ultimately participate in the decision between tolerance and immunity.
摘要
少数抗原反应性淋巴细胞增殖为大量效应细胞是适应性免疫的一个基本特性。推动这一过程的细胞分裂是由抗原、共刺激分子和生长因子受体的信号驱动的，并受细胞周期蛋白依赖性激酶 (CDK) 级联的控制。在这篇观点文章中，我们讨论了 CDK 级联如何通过磷酸化免疫相关转录因子为细胞分裂和分化提供潜在联系，以及该途径的成分如何最终参与耐受和免疫之间的决策。
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