Kotlán B, Böck G, Rajnavölgyi E, Benczur M, Mátyus L, Gyódi E, Huber C, Petrányi G G
National Institute of Haematology and Blood Transfusion PF44, Budapest, Hungary.
Immunol Lett. 1988 Aug;18(4):259-68. doi: 10.1016/0165-2478(88)90172-1.
The effects of alpha- and gamma-interferons (IFN-alpha, -gamma) and of interleukin 2 (IL-2) on the expression of certain differentiation antigens were compared with those of major histocompatibility antigens on human lymphocytes. IFN-gamma and IFN-alpha in high doses significantly increased the expression of T11 (CD2) differentiation antigen, but did not affect the expression of T4 (CD4), T8 (CD8), T3 (CD3) and Leu-7 antigens (HNK-1). Both natural and recombinant IFN-alpha and -beta apparently increased the expression of HLA-ABC antigens and of beta-2 microglobulin (beta 2m) after 16 h incubation. The amount of HLA-DR antigen, however, doubled in a few hours following IFN-gamma treatment. IL-2 affected the expression of CD2 and CD8 antigens only marginally, but did not affect that of CD3 and Leu-7; however, it strongly enhanced the expression of HLA-ABC, HLA-DR, and beta 2m antigens.
将α-干扰素和γ-干扰素（IFN-α、IFN-γ）以及白细胞介素2（IL-2）对某些分化抗原表达的影响，与主要组织相容性抗原对人淋巴细胞表达的影响进行了比较。高剂量的IFN-γ和IFN-α显著增加了T11（CD2）分化抗原的表达，但不影响T4（CD4）、T8（CD8）、T3（CD3）和Leu-7抗原（HNK-1）的表达。天然和重组的IFN-α和IFN-β在孵育16小时后，明显增加了HLA-ABC抗原和β2微球蛋白（β2m）的表达。然而，IFN-γ处理后数小时内，HLA-DR抗原的量增加了一倍。IL-2仅对CD2和CD8抗原的表达有轻微影响，但不影响CD3和Leu-7的表达；然而，它强烈增强了HLA-ABC、HLA-DR和β2m抗原的表达。
