Tarnawski A, Stachura J, Gergely H, Hollander D
Gastroenterology Section, Long Beach VA Medical Center, CA 90822.
J Clin Gastroenterol. 1988;10 Suppl 1:S53-64.
In healthy volunteers, we studied the effect in intragastric administration of 100 ml 40% alcohol or isotonic saline on the ultrastructure of gastric oxyntic mucosa with emphasis on gastric mucosal microvasculature. We found that a single dose of 40% alcohol produces exfoliation of the surface epithelium, damage to the mucosal microvessels, extravasation of red blood cells and plasma from disrupted microvessels, and extensive edema of superficial lamina propria. The ultrastructural changes were seen as early as 5 min after alcohol administration and occurred in the mucosal areas where glandular cells did not show necrotic changes. Alcohol-induced injury was localized predominantly to interfoveolar mucosal areas and only occasionally extended to the neck areas. This study demonstrates that the mucosal microvasculature is a primary target for alcohol-induced injury of the human gastric mucosa.
在健康志愿者中，我们研究了胃内给予100毫升40%酒精或等渗盐水对胃泌酸黏膜超微结构的影响，重点关注胃黏膜微血管系统。我们发现，单剂量40%酒精可导致表面上皮剥脱、黏膜微血管损伤、红细胞和血浆从破裂的微血管外渗，以及固有层浅层广泛水肿。超微结构变化在酒精给药后5分钟即可观察到，且发生在腺细胞未出现坏死变化的黏膜区域。酒精诱导的损伤主要局限于胃小区间黏膜区域，仅偶尔扩展至颈部区域。本研究表明，黏膜微血管系统是酒精诱导的人胃黏膜损伤的主要靶点。
