受前生物无机多聚磷酸盐分子的调控：一种古老的转录独立机制，用以恢复蛋白质的内稳状态。
Chaperoned by prebiotic inorganic polyphosphate molecules: an ancient transcription-independent mechanism to restore protein homeostasis.
机构信息
Department of Cell Biology, University Medical Center Groningen and University of Groningen, 9700 RB Groningen, the Netherlands.
出版信息
Mol Cell. 2014 Mar 6;53(5):685-7. doi: 10.1016/j.molcel.2014.02.023.
PMID:24606917
Abstract
In this issue, Gray et al. (2014) elegantly demonstrate how cells utilize an oxidation-regulated pathway that depletes cellular ATP, lowers proteostatic burden, and leads to accumulation of prebiotic, inorganic polyphosphates with chaperone-like activity for stress protection.
摘要
在本期杂志中，Gray 等人（2014 年）精彩地展示了细胞如何利用一种氧化调节途径，该途径会消耗细胞内的 ATP，降低蛋白质稳态负担，并导致具有类似伴侣活性的前生物、无机多磷酸盐的积累，从而起到应激保护作用。
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