淀粉样前体蛋白如何保护自身不被切割。
How amyloid precursor protein protects itself from cleavage.
作者信息
Lin Hsiang-Kai, van der Wel Patrick C A
机构信息
Department of Structural Biology, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA.
Department of Structural Biology, University of Pittsburgh School of Medicine, Biomedical Science Tower 3, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA.
出版信息
Structure. 2014 Mar 4;22(3):361-2. doi: 10.1016/j.str.2014.02.008.
Abstract
In this issue of Structure, Tang and colleagues probe how the Flemish mutation in amyloid precursor protein (APP) affects its conformation and cleavage by γ-secretase. They provide molecular insight into how an extracellular inhibitory element and cholesterol interactions affect the generation of Aβ peptides.
摘要
在本期《结构》杂志中，唐及其同事探究了淀粉样前体蛋白（APP）中的佛兰芒突变如何影响其构象以及被γ-分泌酶切割的过程。他们提供了关于细胞外抑制元件和胆固醇相互作用如何影响Aβ肽生成的分子见解。
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本文引用的文献
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