Department of Chemistry, Faculty of Education and Science, Albayda'a University, Rada'a 6539551, Yemen.
Department of Industrial Chemistry, Kuvempu University, Shankaraghatta 577451, Karnataka, India.
Carbohydr Polym. 2014 Apr 15;104:151-7. doi: 10.1016/j.carbpol.2014.01.018. Epub 2014 Jan 15.
To reinforce the hydroxyethyl cellulose for using it in biomedical and pharmaceutical applications as a drug delivery systems, the grafting of acrylamide onto hydroxyethyl cellulose (AAm-g-HEC) was achieved by Ce(IV) induced free radical polymerization. The AAm-g-HEC was then blended with sodium alginate (NaAlg) to prepare pH-sensitive interpenetrating network (IPN) microspheres (MPs) by emulsion-crosslinking method using glutaraldehyde (GA) as a crosslinking agent. The produced MPs are almost spherical in nature with smooth surfaces. Diclofenac sodium (DS), an anti-inflammatory drug, was successfully encapsulated into the MPs. The % encapsulation efficiency was found to vary between 54 and 67. The MPs were characterized by DSC, SEM and FTIR spectroscopy. In vitro release studies were carried out in simulated gastric fluid of pH 1.2 for 2h followed by simulated intestinal fluid of pH 7.4 at 37°C. The release data have been fitted to an empirical equation to investigate the diffusional exponent (n), which indicated that the release mechanism shifted from anomalous to the super Case-II transport.
为了增强羟乙基纤维素在生物医药和制药应用中的性能，将丙烯酰胺接枝到羟乙基纤维素（AAm-g-HEC）上，通过 Ce(IV) 引发自由基聚合来实现。然后，将 AAm-g-HEC 与海藻酸钠（NaAlg）混合，通过乳液交联法用戊二醛（GA）作为交联剂制备 pH 敏感的互穿网络（IPN）微球（MPs）。所制备的 MPs 呈天然的近球形，表面光滑。将抗炎药物双氯芬酸钠（DS）成功包封到 MPs 中。发现 %包封效率在 54%到 67%之间变化。通过 DSC、SEM 和 FTIR 光谱对 MPs 进行了表征。在 37°C 下，将体外释放研究在 pH 1.2 的模拟胃液中进行 2 小时，然后在 pH 7.4 的模拟肠液中进行。释放数据符合经验方程，以研究扩散指数（n），表明释放机制从异常转变为超二级传输。
