Chatterjee V K, Ball J A, Davis T M, Proby C, Burrin J M, Bloom S R
Department of Medicine, Hammersmith Hospital, London, United Kingdom.
Metabolism. 1988 Nov;37(11):1089-91. doi: 10.1016/0026-0495(88)90073-x.
The effect of cholinergic blockade with pirenzepine or atropine on growth hormone (GH) release after galanin administration was investigated in five normal male subjects. The mean peak GH response to an infusion of galanin (40 pmol/kg/min for 40 minutes) was significantly reduced from 17.2 mU/L to 2.9 mU/L (P less than .001) with prior administration of pirenzepine (30 mg IV). When galanin was infused at a higher dose (80 pmol/kg/min), this suppression of release by pirenzepine was partially overcome, with GH rising to a mean peak response of 8.0 mU/L (P less than .05). Repeated administration of atropine (two bolus doses of 0.6 mg IV) also failed to abolish the GH response to this higher dose of galanin in two subjects. It has been proposed that cholinergic pathways control GH release via somatostatin, and this study suggests that galanin may also act by modulating hypothalamic somatostatinergic tone either directly or by facilitating cholinergic transmission.
在五名正常男性受试者中，研究了用哌仑西平或阿托品进行胆碱能阻滞对给予甘丙肽后生长激素（GH）释放的影响。预先静脉注射哌仑西平（30mg）后，给予甘丙肽（40pmol/kg/分钟，持续40分钟）时，GH的平均峰值反应从17.2mU/L显著降低至2.9mU/L（P<0.001）。当以更高剂量（80pmol/kg/分钟）输注甘丙肽时，哌仑西平对释放的这种抑制作用被部分克服，GH上升至平均峰值反应8.0mU/L（P<0.05）。在两名受试者中，重复静脉注射阿托品（两剂0.6mg）也未能消除对这种更高剂量甘丙肽的GH反应。有人提出胆碱能途径通过生长抑素控制GH释放，并且该研究表明甘丙肽也可能通过直接调节下丘脑生长抑素能张力或通过促进胆碱能传递来发挥作用。
