内脏受累的全身性婴儿肌纤维瘤病的化疗
Chemotherapy for Generalized Infantile Myofibromatosis With Visceral Involvement.
作者信息
Wu Susan Y, McCavit Timothy L, Cederberg Kevin, Galindo Rene L, Leavey Patrick J
机构信息
*University of Texas Southwestern Medical School †Department of Pediatrics, Division of Hematology-Oncology Departments of §Radiology ¶Pathology ∥Molecular Biology, University of Texas Southwestern Medical Center at Dallas ‡The Center for Cancer and Blood Disorders and Children's Medical Center Dallas, Dallas, TX.
出版信息
J Pediatr Hematol Oncol. 2015 Jul;37(5):402-5. doi: 10.1097/MPH.0000000000000132.
Infantile myofibromatosis (IM) is most commonly limited to cutaneous lesions that resolve spontaneously. However, generalized IM with visceral involvement, which has a reported mortality rate as high as 73%, has been successfully treated with a combination of methotrexate and vinblastine. Here we report the further efficacy of low-dose methotrexate and vinblastine in 2 pediatric patients with IM and visceral involvement and review the literature describing chemotherapy for these patients.
婴儿肌纤维瘤病（IM）最常见的情况是局限于皮肤病变，且这些病变可自发消退。然而，有内脏受累的全身性IM，据报道死亡率高达73%，已通过甲氨蝶呤和长春碱联合治疗成功治愈。在此，我们报告低剂量甲氨蝶呤和长春碱对2例有内脏受累的IM患儿的进一步疗效，并回顾描述这些患者化疗情况的文献。
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