Departments of Pediatrics.
Neurosurgery.
J Pediatr Hematol Oncol. 2023 Oct 1;45(7):e921-e923. doi: 10.1097/MPH.0000000000002717. Epub 2023 Jul 13.
Infantile myofibromatosis (IM) is a rare benign tumor of infancy. Cases with solitary and multicentric disease usually spontaneously regress, but multicentric disease with visceral involvement carries a poor prognosis. Few cases of multicentric disease with central nervous system (CNS) involvement have been reported, and none report survival.
We present a newborn with multicentric IM with cutaneous, visceral, and CNS involvement. She was treated with vinblastine, methotrexate, and the novel addition of intrathecal methotrexate with treatment response after 1 year of therapy.
Multicentric IM with CNS involvement can be successfully treated with a multimodal approach of chemotherapy with the addition of intrathecal methotrexate and surgery.
婴儿肌纤维瘤病（IM）是一种罕见的婴儿良性肿瘤。单发和多中心疾病的病例通常会自发消退，但伴有内脏受累的多中心疾病预后不良。有少数多中心疾病伴有中枢神经系统（CNS）受累的病例报告，且均无生存报告。
我们报告了一例新生儿患有多中心 IM，伴皮肤、内脏和 CNS 受累。她接受了长春碱、甲氨蝶呤治疗，并新加入了鞘内注射甲氨蝶呤，在 1 年的治疗后有治疗反应。
多中心伴有 CNS 受累的 IM 可以通过化疗联合鞘内注射甲氨蝶呤和手术的多模式方法成功治疗。
