Yang Wenli, Zhao Sanjun, Liu Fei, Sun Minglei
Department of Stomatology, The First Affiliated Hospital of Zhengzhou, University, Zhengzhou, China, No 1 Jian she East Road, Zhengzhou, Henan 450052, China,
Med Oral Patol Oral Cir Bucal. 2014 Jul 1;19(4):e414-8. doi: 10.4317/medoral.19399.
Mandibular resection for oral cancer is often necessary to achieve an adequate margin of tumor clearance.Mandibular resection has been associated with a poor health-related quality of life (HRQOL), particularly before free fibula flap to reconstruct the defect. The aim of this study was to evaluate health-related quality of life in patients who have had mandibular resections of oral cancer and reconstruction with free fibula flap.
There were 115 consecutive patients between 2008 and 2011 who were treated by primary surgery for oral squamous cell carcinoma, 34 patients had a mandibular resection. HRQOL was assessed by means of the 14-item Oral Health Impact Profile (OHIP-14) and University of Washington Quality of Life (UW-QOL) questionnaires after 12 months postoperatively.
In the UW-QOL the best-scoring domain was mood, whereas the lowest scores were for chewing and saliva. In the OHIP-14 the lowest-scoring domain was social disability, followed by handicap, and psychological disability.
Mandible reconstruction with free fibula flap would have significantly influenced on patients'quality of life and oral functions.The socio-cultural data show a fairly low level of education for the majority of patients.
口腔癌的下颌骨切除术对于实现足够的肿瘤清除切缘往往是必要的。下颌骨切除术与健康相关生活质量（HRQOL）较差有关，尤其是在采用游离腓骨瓣重建缺损之前。本研究的目的是评估接受口腔癌下颌骨切除术并采用游离腓骨瓣重建的患者的健康相关生活质量。
2008年至2011年间，共有115例接受口腔鳞状细胞癌一期手术治疗的患者，其中34例进行了下颌骨切除术。术后12个月通过14项口腔健康影响量表（OHIP - 14）和华盛顿大学生活质量（UW - QOL）问卷对HRQOL进行评估。
在UW - QOL中，得分最高的领域是情绪，而得分最低的是咀嚼和唾液方面。在OHIP - 14中，得分最低的领域是社会功能障碍，其次是残疾和心理功能障碍。
游离腓骨瓣下颌骨重建对患者的生活质量和口腔功能有显著影响。社会文化数据显示，大多数患者的教育水平相当低。
