Department of Oncology, Centre Hospitalier Universitaire Vaudois and Department of Biochemistry, University of Lausanne, Epalinges, Switzerland; and.
Blood. 2014 Apr 24;123(17):2614-24. doi: 10.1182/blood-2013-12-297317. Epub 2014 Mar 7.
Lymphatic vasculature is increasingly recognized as an important factor both in the regulation of normal tissue homeostasis and immune response and in many diseases, such as inflammation, cancer, obesity, and hypertension. In the last few years, in addition to the central role of vascular endothelial growth factor (VEGF)-C/VEGF receptor-3 signaling in lymphangiogenesis, significant new insights were obtained about Notch, transforming growth factor β/bone morphogenetic protein, Ras, mitogen-activated protein kinase, phosphatidylinositol 3 kinase, and Ca(2+)/calcineurin signaling pathways in the control of growth and remodeling of lymphatic vessels. An emerging picture of lymphangiogenic signaling is complex and in many ways distinct from the regulation of angiogenesis. This complexity provides new challenges, but also new opportunities for selective therapeutic targeting of lymphatic vasculature.
淋巴管系统在调节组织内稳态和免疫反应以及多种疾病（如炎症、癌症、肥胖和高血压）中起着重要作用，这一点越来越受到重视。在过去几年中，除了血管内皮生长因子（VEGF）-C/VEGF 受体-3 信号通路在淋巴管生成中的核心作用外，Notch、转化生长因子 β/骨形态发生蛋白、Ras、丝裂原活化蛋白激酶、磷酸肌醇 3 激酶和 Ca（2+）/钙调神经磷酸酶信号通路在控制淋巴管生长和重塑方面也有了重要的新发现。淋巴管生成信号通路的一个新的复杂图景在许多方面与血管生成的调控不同。这种复杂性不仅带来了新的挑战，也为选择性靶向淋巴管血管系统提供了新的机会。
