Ghosh K, Hasan S W, Kumar S
Department of Haematology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Trop Geogr Med. 1988 Jul;40(3):209-12.
1561 consecutive adult patients who were not suffering from any haematological or malignant disorder and 40 healthy volunteers were screened for hereditary persistence of foetal haemoglobin (HPFH). Two unrelated heterozygotes were detected. Both these heterozygotes displayed heterocellular distribution of foetal haemoglobin in 14-18% of red cells constituting 3.1-4.3% alkali resistant foetal haemoglobin. No case of pancellular variety of HPFH was detected. The heterocellular variety of HPFH is present in 1:800 individuals in Northwest India.
对1561例未患任何血液学或恶性疾病的成年患者以及40名健康志愿者进行了胎儿血红蛋白遗传性持续存在（HPFH）筛查。检测到两名无关的杂合子。这两名杂合子均在14% - 18%的红细胞中表现出胎儿血红蛋白的异细胞分布，构成3.1% - 4.3%的耐碱性胎儿血红蛋白。未检测到全细胞型HPFH病例。在印度西北部，HPFH的异细胞型在1:800的个体中存在。
