Taşolar Hakan, Mete Türkan, Ballı Mehmet, Altun Burak, Çetin Mustafa, Yüce Tuncay, Taşolar Sevgi, Otlu Ömür, Bayramoğlu Adil, Pekdemir Hasan
Training and Research Hospital, Department of Cardiology, Adiyaman University, Adiyaman, Turkey.
J Obstet Gynaecol Res. 2014 Apr;40(4):1059-66. doi: 10.1111/jog.12308. Epub 2014 Mar 10.
Even though polycystic ovary syndrome (PCOS) is characterized by increased inflammatory activity and insulin resistance, there is no clinical data about whether risk of atrial fibrillation are increased in these patients. We aimed to evaluate atrial conduction parameters predicting atrial involvement in this patient group.
The study population comprised 50 women 18-40 years of age who had been diagnosed with PCOS. The patients were divided into two groups: lean women (L-PCOS) with a body mass index (BMI) under 25 kg/m² and obese women (O-PCOS) with a BMI greater than 30 kg/m². Twenty-five age-matched lean healthy women were enrolled voluntarily as the control group. Difference between maximum and minimum P-wave duration was calculated and was defined as P-wave dispersion (Pd). Inter- and intra-atrial electromechanical delays (inter-AED, intra-AED, respectively) were measured with tissue Doppler imaging.
Inter- and intra-AED parameters were higher in the L-PCOS group when compared with control subjects (anova, P=0.004 and P=0.013, respectively), and were also significantly higher in the O-PCOS group compared with other groups (anova, P<0.001 for both). The regression analyses indicated that Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR) (β=0.603, P<0.001) and BMI (β=0.379, P<0.001) were the independent predictors of inter-AED, HOMA-IR (β=0.835, P<0.001) was an independent predictor of intra-AED, and BMI (β=0.457, P=0.006) and the left atrial diameter (β=0.350, P<0.034) were independent predictors of Pd.
Consequently, our findings provide data regarding prolonged atrial conduction parameters in PCOS patients, especially when accompanied by obesity.
尽管多囊卵巢综合征（PCOS）的特征是炎症活动增加和胰岛素抵抗，但尚无关于这些患者心房颤动风险是否增加的临床数据。我们旨在评估预测该患者群体心房受累的心房传导参数。
研究人群包括50名年龄在18至40岁之间、已被诊断为PCOS的女性。患者被分为两组：体重指数（BMI）低于25kg/m²的瘦女性（L-PCOS）和BMI大于30kg/m²的肥胖女性（O-PCOS）。25名年龄匹配的瘦健康女性自愿入选作为对照组。计算最大和最小P波持续时间之间的差异，并将其定义为P波离散度（Pd）。使用组织多普勒成像测量心房内和心房间的机电延迟（分别为心房间AED、心房内AED）。
与对照组相比，L-PCOS组的心房内和心房间AED参数更高（方差分析，P分别为0.004和0.013），与其他组相比，O-PCOS组的这些参数也显著更高（方差分析，两者P均<0.001）。回归分析表明，稳态模型评估-胰岛素抵抗（HOMA-IR）（β=0.603，P<0.001）和BMI（β=0.379，P<0.0且）是心房间AED的独立预测因素，HOMA-IR（β=0.835，P<0.001）是心房内AED的独立预测因素，BMI（β=0.457，P=0.006）和左心房直径（β=0.350，P<0.034）是Pd的独立预测因素。
因此，我们的研究结果提供了关于PCOS患者心房传导参数延长的数据，尤其是伴有肥胖时。
