15 年间单中心滤泡状甲状腺癌的临床病理与预后分析。

Clinicopathological and prognostic analysis of follicular thyroid carcinoma in a single institute over a 15-year period.

机构信息

Cancer Center, First Affiliated Hospital, Zhejiang University School of Medicine, 79th Qingchun Road, Hangzhou 310003, China.

Department of Pathology, First Affiliated Hospital, Zhejiang University School of Medicine, 79th Qingchun Road, Hangzhou 310003, China.

出版信息

Eur J Surg Oncol. 2014 Jul;40(7):869-74. doi: 10.1016/j.ejso.2014.01.012. Epub 2014 Feb 13.

DOI:10.1016/j.ejso.2014.01.012

PMID:24613740

Abstract

BACKGROUND

This study was to evaluate the clinicopathological and prognostic features of follicular thyroid carcinoma (FTC) in our institute over a 15-year period.

METHODS

The clinical features, management and outcome of 134 consecutive patients were analyzed according to the time of diagnosis: Group I (1997-2001), Group II (2002-2006), and Group III (2007-2011).

RESULTS

As time advanced, the ratio of FTC to papillary thyroid carcinoma decreased from 8.7% in group I to 4.3% in group III (p = 0.000). The percentage of patients undergoing total thyroidectomy seemed to be more commonly used in the later periods - from 10.5% in group I to 21.8% in group II and 18.9% in group III. The median diameter of tumors in group I was 4.2 cm and it showed a sharp decrease to 2.8 cm in group II and 2.9 cm in group III respectively. There was a trend towards a higher stage in patients from Group I vs. patients from Groups II and III (stage IV, 15.8% vs. 2.2% and 4.3%, p = 0.072). The outcome was improved in terms of disease-free survival (DFS). The 3-year DFS rate improved from 77.8% in group I to 93.7% in group II and 100% in group III (p = 0.008).

CONCLUSIONS

The clinical features, management and outcome of FTC patients changed over 15-year period. Patients diagnosed after 2001 had a better prognosis. This improvement was probably related to earlier diagnosis with smaller tumor size and presentation at earlier tumor stage.

摘要

背景

本研究旨在评估我院 15 年来滤泡状甲状腺癌（FTC）的临床病理特征和预后。

方法

根据诊断时间，对 134 例连续患者的临床特征、治疗和结局进行分析：第 I 组（1997-2001 年）、第 II 组（2002-2006 年）和第 III 组（2007-2011 年）。

结果

随着时间的推移，FTC 与甲状腺乳头状癌的比例从第 I 组的 8.7%下降至第 III 组的 4.3%（p=0.000）。全甲状腺切除术的比例在后期似乎更为常见——从第 I 组的 10.5%增加至第 II 组的 21.8%和第 III 组的 18.9%。第 I 组肿瘤的中位直径为 4.2cm，第 II 组和第 III 组分别急剧下降至 2.8cm 和 2.9cm。第 I 组患者的分期明显高于第 II 组和第 III 组（IV 期，15.8%比 2.2%和 4.3%，p=0.072）。无病生存率（DFS）有所改善。第 I 组的 3 年 DFS 率从 77.8%提高至第 II 组的 93.7%和第 III 组的 100%（p=0.008）。