Department of Neurology/Clinical Neurophysiolgy, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA; Department of Clinical Neurological Sciences, Western University, London, Canada.
Department of Clinical Neurological Sciences, Western University, London, Canada.
Epilepsy Behav. 2014 Apr;33:24-30. doi: 10.1016/j.yebeh.2014.02.003. Epub 2014 Mar 12.
There is limited information on neuroimaging changes in status epilepticus (SE). The objective of this study was to characterize the abnormalities associated with SE in cranial MRI of patients with SE.
A retrospective review of our records from 2001 to 2010 identified 203 patients with SE. Magnetic resonance imaging (MRI) changes considered were not attributable to any neurological disorder.
Ten patients who met the inclusion criteria were found to have significant abnormalities. Magnetic resonance imaging findings included increased T2 signal changes in the gray and/or white matter with corresponding diffusion-weighted imaging (DWI) abnormalities (n=9). Apparent diffusion coefficient (ADC) values were both reduced (n=3) and increased (n=3). Other findings included changes affecting one hemisphere, a perilesional and homologous region, hippocampal changes, and findings in the thalamus, basal ganglia, brain stem, and cerebellum.
Magnetic resonance imaging changes were diffuse. Notably, MRI changes were found to involve the brain stem, cerebellum, basal ganglia, and thalamus. Magnetic resonance imaging changes in the latter areas have not been previously well described. In addition, MRI changes tended to evolve after 1week; therefore, serial MRI is recommended in order to follow and highlight the MRI changes related to the neuroanatomic involvement seen in status epilepticus.
关于癫痫持续状态（SE）的神经影像学改变的信息有限。本研究的目的是描述 SE 患者颅脑 MRI 中与 SE 相关的异常。
对 2001 年至 2010 年的病历进行回顾性研究，确定了 203 例 SE 患者。考虑的 MRI 改变与任何神经疾病无关。
发现 10 名符合纳入标准的患者存在明显异常。MRI 发现包括灰质和/或白质 T2 信号改变，伴相应的弥散加权成像（DWI）异常（n=9）。表观扩散系数（ADC）值降低（n=3）和升高（n=3）。其他发现包括单侧病变、病变周围和同源区域、海马变化以及丘脑、基底节、脑干和小脑变化。
MRI 改变是弥漫性的。值得注意的是，MRI 改变涉及脑干、小脑、基底节和丘脑。以前没有很好地描述这些区域的 MRI 变化。此外，MRI 改变倾向于在 1 周后出现；因此，建议进行连续 MRI 以跟踪和突出显示与 SE 中所见的神经解剖受累相关的 MRI 变化。
