Stournaras Christos, Gravanis Achilles, Margioris Andrew N, Lang Florian
Department of Biochemistry, University of Crete Medical School, Heraklion, Greece; Department of Physiology, University of Tübingen, Tübingen, Germany.
Cytoskeleton (Hoboken). 2014 May;71(5):285-93. doi: 10.1002/cm.21172. Epub 2014 Mar 25.
Early actin cytoskeleton reorganization is an important regulatory step of membrane-initiated, non-genomic steroid hormone actions. Specific intracellular signaling cascades control the rapid alterations of actin polymerization in a variety of cell models. Moreover, actin remodeling is a decisive component in the signaling of hormone-induced early and late cellular responses. This article briefly summarizes the current knowledge on the steroid hormone-induced early actin cytoskeleton rearrangements. It focuses on the current progress to characterize the glucocorticoid- and androgen-initiated, tissue-specific actin signaling pathways and discusses the plethora of cellular responses that are regulated by the early actin redistribution. It also provides insights into the potential clinical significance of actin dynamics and actin-specific molecular signaling for nongenomic steroid hormone actions on tumor cells. © 2014 Wiley Periodicals, Inc.
早期肌动蛋白细胞骨架重组是膜启动的非基因组类固醇激素作用的重要调节步骤。特定的细胞内信号级联反应在多种细胞模型中控制肌动蛋白聚合的快速变化。此外，肌动蛋白重塑是激素诱导的早期和晚期细胞反应信号传导中的决定性组成部分。本文简要总结了目前关于类固醇激素诱导的早期肌动蛋白细胞骨架重排的知识。它着重介绍了表征糖皮质激素和雄激素启动的组织特异性肌动蛋白信号通路的当前进展，并讨论了由早期肌动蛋白重新分布调节的大量细胞反应。它还深入探讨了肌动蛋白动力学和肌动蛋白特异性分子信号传导对于非基因组类固醇激素对肿瘤细胞作用的潜在临床意义。© 2014威利期刊公司。
