Tandon R, Channabasavanna S M, Greden J F
University of Michigan Medical Center, Ann Arbor.
Acta Psychiatr Scand. 1988 Sep;78(3):289-97. doi: 10.1111/j.1600-0447.1988.tb06339.x.
To evaluate the question of whether "mixed" bipolar disorder is a distinct entity, we compared selected cerebrospinal fluid (CSF) biochemical parameters from patients with bipolar disorder, mixed, to those with mania and major depression. Fourteen patients in each category (DSM-III) were studied with regard to CSF HVA, 5HIAA, sodium, potassium, calcium, and magnesium levels under carefully controlled conditions. CSF HVA, 5HIAA, and sodium were found to be significantly higher in manics than in major depressives. Discriminant analysis of the biochemical variables of the mixed affective group identified two biochemically distinct and clinically different subgroups of seven patients each, one resembling the manic group and the other the major depressive group. These findings suggest that mixed affective states do not exist as a separate entity, but are composed of two subgroups obtained from the manic and major depressive categories.
为评估“混合性”双相情感障碍是否为一个独特实体的问题，我们比较了双相情感障碍混合型患者与躁狂症患者及重度抑郁症患者脑脊液（CSF）的特定生化参数。在严格控制的条件下，对每类（DSM-III）的14名患者的脑脊液高香草酸（HVA）、5-羟吲哚乙酸（5HIAA）、钠、钾、钙和镁水平进行了研究。发现躁狂症患者脑脊液中的HVA、5HIAA和钠显著高于重度抑郁症患者。对混合情感组生化变量的判别分析确定了两个生化特征不同且临床症状不同的亚组，每组各有7名患者，一组类似于躁狂组，另一组类似于重度抑郁组。这些发现表明，混合情感状态并非作为一个单独的实体存在，而是由从躁狂和重度抑郁类别中获得的两个亚组组成。
