Agren H, Terenius L
J Affect Disord. 1985 Jul;9(1):25-34. doi: 10.1016/0165-0327(85)90006-0.
CSF levels of radioreceptorassayed endorphins Fraction I (EndFI, n = 92) and homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) (n = 118) were measured in patients with major depressive disorders according to Research Diagnostic Criteria (18% were psychotic; 11% hallucinated during the peak of the depressive episode). CSF measures (both "raw" variables and ranks) were uni- and multivariately correlated with both dichotomized and scored measures of hallucinations of any type. Hallucinations were statistically strongly associated with higher HVA levels, irrespective of prior medication with neuroleptics, and with the interactive product HVA X EndFI and the interactive ratio HVA/5-HIAA. Results suggest interactions between dopaminergic, serotonergic and endorphinergic neurotransmission being involved in the biochemical substrate of depressive hallucinatory episodes.
根据研究诊断标准，对患有重度抑郁症的患者（18%为精神病性患者；11%在抑郁发作高峰期出现幻觉）测定了脑脊液中放射受体测定的内啡肽I组分（EndFI，n = 92）、高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）（n = 118）的水平。脑脊液测量值（“原始”变量和秩）与任何类型幻觉的二分法和评分测量值进行了单变量和多变量相关分析。无论之前是否使用抗精神病药物，幻觉在统计学上都与较高的HVA水平以及交互产物HVA×EndFI和交互比率HVA/5-HIAA密切相关。结果表明，多巴胺能、5-羟色胺能和内啡肽能神经传递之间的相互作用参与了抑郁性幻觉发作的生化基础。
