潜伏性和活动性肺结核：注射吸毒者的评估
Latent and active tuberculosis: evaluation of injecting drug users.
作者信息
Mamani Mojgan, Majzoobi Mohammad Mahdi, Torabian Saadat, Mihan Ronak, Alizadeh Kamyab
机构信息
Department of Infectious Diseases, Hamedan University of Medical Sciences, Hamedan, IR Iran.
Department of Social Medicine, Hamedan University of Medical Sciences, Hamedan, IR Iran.
出版信息
Iran Red Crescent Med J. 2013 Sep;15(9):775-9. doi: 10.5812/ircmj.6283. Epub 2013 Sep 5.
BACKGROUND
There is a high risk of tuberculosis (TB) infection among injecting drug users (IDUs).
OBJECTIVES
This study aimed to determine the frequency of latent and active TB infection among IDUs.
MATERIALS AND METHODS
In a cross-sectional study between 2008 and 2009, IDUs referred to the methadone maintenance treatment (MMT) centers in Hamedan-Iran, undergone tuberculin skin test (PPD; purified protein derivative) were recruited. The participants with positive results for PPD test (> 5 mm and > 10 mm in HIV positive and negative cases), undergone other complementary procedures such as chest-X-ray and sputum smear test.
RESULTS
Overall, 268 IDUs between 18 and 70 (mean: 34.5 [8.2]) years were included in the study. PPD test had positive findings in 49 cases (18.3%). There was no significant difference of PPD positivity between HIV positive and negative participants (17.7% vs. 18.5%). An active TB was found among IDUs.
CONCLUSIONS
The high prevalence of latent and active TB among IDUs indicates the need for TB screening tests among this population.
背景
注射吸毒者（IDU）感染结核病（TB）的风险很高。
目的
本研究旨在确定注射吸毒者中潜伏性和活动性结核感染的频率。
材料与方法
在2008年至2009年的一项横断面研究中，招募了转诊至伊朗哈马丹美沙酮维持治疗（MMT）中心并接受结核菌素皮肤试验（PPD；纯化蛋白衍生物）的注射吸毒者。PPD试验结果呈阳性（HIV阳性和阴性病例中分别>5mm和>10mm）的参与者接受了其他补充检查，如胸部X光和痰涂片检查。
结果
总体而言，268名年龄在18至70岁（平均：34.5[8.2]岁）的注射吸毒者纳入了研究。PPD试验有阳性结果的有49例（18.3%）。HIV阳性和阴性参与者之间PPD阳性率无显著差异（17.7%对18.5%）。在注射吸毒者中发现了活动性结核病。
结论
注射吸毒者中潜伏性和活动性结核的高患病率表明该人群需要进行结核病筛查试验。
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