Holden M J, Colombini M
Department of Zoology, University of Maryland, College Park 20742.
FEBS Lett. 1988 Dec 5;241(1-2):105-9. doi: 10.1016/0014-5793(88)81040-8.
The mitochondrial outer membrane channel, VDAC, serves as the primary permeability pathway for metabolite flux between cytoplasmic and mitochondrial compartments. VDAC can occupy several conformational states differing in ion conductivity. Small transmembrane potentials cause transitions from open- to closed-channel conformations. A soluble mitochondrial protein enhances the channel's response to voltage by increasing the rate of channel closing; inducing the occupation of lower conductance states; and decreasing the rate of channel reopening. This protein modulator acts at very low concentrations and its role in the cell may be to regulate the permeability of the mitochondrial outer membrane by inducing channel closure.
线粒体外膜通道孔蛋白（VDAC）是细胞质与线粒体区室之间代谢物通量的主要通透途径。VDAC可呈现几种离子电导率不同的构象状态。小的跨膜电位会导致通道构象从开放态转变为关闭态。一种可溶性线粒体蛋白通过提高通道关闭速率、诱导占据低电导状态以及降低通道重新开放速率来增强通道对电压的响应。这种蛋白调节剂在极低浓度下起作用，其在细胞中的作用可能是通过诱导通道关闭来调节线粒体外膜的通透性。
