免疫反应的独特型控制

Idiotypic control of the immune response.

作者信息

Valderrama R, Eggers A E, Revan S, Moomjy M, Frost M, Pipia P, Di Paola M

机构信息

Department of Neurology, SUNY Health Science Center, Brooklyn 11203.

出版信息

J Neuroimmunol. 1988 Dec;20(2-3):269-76. doi: 10.1016/0165-5728(88)90174-9.

DOI:10.1016/0165-5728(88)90174-9

PMID:2461958

Abstract

Anti-idiotypic antibodies are antibodies against the antigenic determinants (idiotypes) of an antibody's antigen-binding region. Anti-idiotypes can bind near (Ab2 gamma) or away (Ab2 alpha) from the antigen-combining site or can carry the internal image of the antigen (Ab2 beta). Idiotypes and anti-idiotypes have been described in T- and B-cell systems. They have been used in basic research to purify and characterize receptors and ligands against receptors, to treat tumors, to make vaccines and to diagnose and suppress the immune response. In experimental myasthenia gravis anti-idiotypes protect animals against the disease, block idiotype binding and share idiotypic specificities.

摘要

抗独特型抗体是针对抗体抗原结合区的抗原决定簇（独特型）的抗体。抗独特型抗体可以在靠近抗原结合位点处（Ab2γ）或远离抗原结合位点处（Ab2α）结合，或者可以携带抗原的内影像（Ab2β）。独特型和抗独特型已在T细胞和B细胞系统中有所描述。它们已被用于基础研究，以纯化和表征针对受体的受体和配体、治疗肿瘤、制备疫苗以及诊断和抑制免疫反应。在实验性重症肌无力中，抗独特型抗体可保护动物免受该病侵害、阻断独特型结合并具有独特型特异性。