抗逆转录病毒药物预防 HIV：何时应推荐使用？

Antiretrovirals for HIV prevention: when should they be recommended?

机构信息

Department of Internal Medicine, HIV Translational Research Unit (HTRU), Ghent University and Ghent University Hospital, Ghent, Belgium.

出版信息

Expert Rev Anti Infect Ther. 2014 Apr;12(4):431-45. doi: 10.1586/14787210.2014.896739.

DOI:10.1586/14787210.2014.896739

PMID:24621251

Abstract

Since the introduction of the first antiretroviral agent for HIV treatment, information on antiretroviral therapy (ART) effectiveness has grown continuously. In recent years, there has also been a growth of interest in use of ART for the prevention of HIV transmission, either by reducing the infectivity of the infected person or by protecting the uninfected individuals from HIV acquisition. The purpose of this review is to summarize the body of evidence available for treatment as prevention and pre-exposure prophylaxis and their effectiveness in prevention of infection. In addition, our aim is to discuss the operational aspects of both prevention strategies and to provide commentary for future HIV prevention programs.

摘要

自第一个抗逆转录病毒药物用于 HIV 治疗以来，有关抗逆转录病毒疗法 (ART) 效果的信息不断增加。近年来，人们对使用 ART 进行 HIV 传播预防的兴趣也有所增加，这种预防可以通过降低感染者的传染性，或者通过保护未感染者免受 HIV 感染来实现。本综述的目的是总结现有关于治疗即预防和暴露前预防的证据，并评估它们在预防感染方面的效果。此外，我们的目的是讨论这两种预防策略的操作方面，并为未来的 HIV 预防计划提供评论。