Rosen B, Ovsyshcher I A, Zimlichman R
Department of Medicine, Ben Gurion University, Beer Sheva, Israel.
Pacing Clin Electrophysiol. 1988 Nov;11(11 Pt 1):1555-8. doi: 10.1111/j.1540-8159.1988.tb06273.x.
We present two patients who developed complete heart block due to treatment with methyldopa. After discontinuing methyldopa, conduction disturbances completely disappeared and recurred upon rechallenge with the medication. It is assumed that methyldopa can impair the myocardial conduction system by its central sympatholytic effect. Conduction anomalies should be excluded prior to treatment with methyldopa, and during treatment with the medication, the patients should be routinely screened for the presence of conduction anomalies.
我们报告了两名因使用甲基多巴治疗而发生完全性心脏传导阻滞的患者。停用甲基多巴后，传导障碍完全消失，再次使用该药物时复发。据推测，甲基多巴可通过其中枢性抗交感神经作用损害心肌传导系统。在使用甲基多巴治疗前应排除传导异常，并且在用药期间，应对患者进行传导异常的常规筛查。
