von Arnim U, Miehlke S, Madisch A, Vieth M, Straumann A, Malfertheiner P
Klinik für Gastroenterologie, Hepatologie und Infektiologie, Universitätsklinikum Magdeburg AöR, Magdeburg.
Magen-Darm-Zentrum, Facharztzentrum Eppendorf, Hamburg.
Z Gastroenterol. 2014 Mar;52(3):296-305. doi: 10.1055/s-0033-1356135. Epub 2014 Mar 12.
Eosinophilic esophagitis (EoE) is a clinicopathological condition of the esophagus that has become increasingly recognised over the last decade. EoE represents a chronic immune-mediated inflammatory disease of the esophagus. In adults dysphagia is the predominant symptom. Upper gastrointestinal endoscopy is required in order to take biopsies from the esophagus. The diagnose is confirmed histologically by typical eosinophilic infiltration of the esophagus mucosa. Until now there is no approved therapy world-wide although we know that topic and systemic steroids are highly effective in EoE. Elimination diet is another option and in well selected patients endoscopic balloon dilation represents a therapeutic possibility.
嗜酸性粒细胞性食管炎（EoE）是一种食管的临床病理状况，在过去十年中已得到越来越多的认识。EoE是一种食管的慢性免疫介导性炎症性疾病。在成人中，吞咽困难是主要症状。需要进行上消化道内镜检查以便从食管获取活检组织。通过食管黏膜典型的嗜酸性粒细胞浸润在组织学上确诊。尽管我们知道局部和全身用类固醇在EoE中非常有效，但到目前为止全球尚无获批的治疗方法。排除饮食是另一种选择，对于精心挑选的患者，内镜下球囊扩张是一种治疗可能性。
