Tan Carlyn R, Yaffee Patrick M, Jamil Laith H, Lo Simon K, Nissen Nicholas, Pandol Stephen J, Tuli Richard, Hendifar Andrew E
Samuel Oschin Comprehensive Cancer Center, Cedars Sinai Medical Center Los Angeles, CA, USA.
Department of Medicine, David Geffen School of Medicine Los Angeles, CA, USA.
Front Physiol. 2014 Mar 3;5:88. doi: 10.3389/fphys.2014.00088. eCollection 2014.
Over the last decade, we have gained new insight into the pathophysiology of cachexia associated with pancreatic cancer. Unfortunately, its treatment is complex and remains a challenge. Pancreatic cancer cachexia is a multifactorial syndrome characterized by uncompensated adipose tissue and skeletal muscle loss in the setting of anorexia that leads to progressive functional impairment. This paper will review the current concepts of pancreatic cancer cachexia, its assessment and pathophysiology as well as current and future treatments. The successful management of pancreatic cancer cachexia will likely require a multimodal approach that includes nutritional support and combination pharmaceutical interventions.
在过去十年中，我们对与胰腺癌相关的恶病质的病理生理学有了新的认识。不幸的是，其治疗复杂，仍然是一项挑战。胰腺癌恶病质是一种多因素综合征，其特征是在厌食症背景下出现脂肪组织和骨骼肌无法代偿性丢失，进而导致进行性功能障碍。本文将综述胰腺癌恶病质的当前概念、评估、病理生理学以及当前和未来的治疗方法。成功管理胰腺癌恶病质可能需要多模式方法，包括营养支持和联合药物干预。
