Němejcová Kristýna, Dundr Pavel
Cesk Patol. 2014 Jan;50(1):34-7.
We report a case of an 84-year old female with granular cell atypical fibroxanthoma. The patient had an exophytic cutaneous tumor without ulceration localized on the left thigh. Histologically, the tumor consisted of a large epitheloid and spindle cells with a moderate to abundant amount of eosinophilic granular cytoplasm. The nuclei were irregular with coarse chromatin and some exhibited prominent nucleoli. Some of the tumor cells displayed atypical bizarre pleomorphic nuclei. Mitotic figures were sparse. Immunohistochemically, the tumor cells showed diffuse positivity for vimentin, CD10, NKi/C3 and CD68 (KP1). CD68 (PGM1) was positive only focally. Other markers examined, which included Melan A, HMB45, S-100 protein, cytokeratin AE1/AE3, desmin, h-caldesmon, α-smooth muscle actin, NSE, CD1a, CD34, and CD31 were negative. A granular cell variant of atypical fibroxanthoma is rare, and only a few cases have been reported in the literature to date.
dermal tumor - atypical fibroxanthoma - granular cells - cytoplasmatic granules - granular cell tumors.
我们报告一例84岁女性的颗粒细胞非典型纤维黄色瘤病例。患者左大腿有一个无溃疡的外生性皮肤肿瘤。组织学上，肿瘤由大的上皮样细胞和梭形细胞组成，伴有中等至丰富的嗜酸性颗粒状细胞质。细胞核不规则，染色质粗糙，部分细胞核仁明显。部分肿瘤细胞显示非典型奇异多形性核。有丝分裂象稀少。免疫组化显示，肿瘤细胞波形蛋白、CD10、NKi/C3和CD68（KP1）弥漫阳性。CD68（PGM1）仅局灶阳性。检测的其他标志物，包括Melan A、HMB45、S-100蛋白、细胞角蛋白AE1/AE3、结蛋白、h-钙调蛋白、α-平滑肌肌动蛋白、神经元特异性烯醇化酶、CD1a、CD34和CD31均为阴性。非典型纤维黄色瘤的颗粒细胞变体罕见，迄今为止文献中仅报道了少数病例。
皮肤肿瘤；非典型纤维黄色瘤；颗粒细胞；细胞质颗粒；颗粒细胞瘤
