新型N'-(4-芳氧基亚苄基)-1H-苯并咪唑-2-碳酰肼衍生物作为抗结核药物的合成及生物学评价
Synthesis and biological evaluation of novel N' (4-aryloxybenzylidene)- 1H-benzimidazole-2 carbohydrazide derivatives as anti-tubercular agents.
作者信息
Siddiki Afsar Ali, Bairwa Vinod Kumar, Telvekar Vikas N
机构信息
Institute of Chemical Technology, Department of Pharmaceutical Sciences and Technology, Mumbai 400 019, India.
出版信息
Comb Chem High Throughput Screen. 2014;17(7):630-8. doi: 10.2174/1386207317666140314092412.
A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method. These compounds showed good antituberculosis activity with minimum inhibitory concentration (MIC) value of the range of 1.5-25 µg/mL.
通过分子杂交技术合成了一系列结构新颖的（E）-N'-（4-芳氧基亚苄基）-1H-苯并咪唑-2-碳酰肼衍生物。使用刃天青微量滴定法（REMA）对所有这些化合物针对结核分枝杆菌H37Rv菌株进行了评估。这些化合物表现出良好的抗结核活性，最低抑菌浓度（MIC）值在1.5-25μg/mL范围内。
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