Zenker N, Hubbard L S, Wright J
Department of Medicinal Chemistry/Pharmacognosy, School of Pharmacy, University of Maryland, Baltimore 21201.
J Nat Prod. 1988 Sep-Oct;51(5):862-5. doi: 10.1021/np50059a008.
RS-Goitrin can be conveniently prepared by a simplification of the Ettlinger procedure. Goitrin is a moderate inhibitor of purified bovine adrenal dopamine beta-hydroxylase. The administration of goitrin leads to a depression of brain norepinephrine and to an elevation of heart and adrenal dopamine.
通过简化埃特林格方法可以方便地制备RS-戈特里因。戈特里因是纯化牛肾上腺多巴胺β-羟化酶的中度抑制剂。给予戈特里因会导致脑去甲肾上腺素水平降低，以及心脏和肾上腺多巴胺水平升高。
