Inhibition of dopamine beta-hydroxylase by goitrin, a natural antithyroid compound.
作者信息
Zenker N, Hubbard L S, Wright J
机构信息
Department of Medicinal Chemistry/Pharmacognosy, School of Pharmacy, University of Maryland, Baltimore 21201.
出版信息
J Nat Prod. 1988 Sep-Oct;51(5):862-5. doi: 10.1021/np50059a008.
PMID:2462616
Abstract
RS-Goitrin can be conveniently prepared by a simplification of the Ettlinger procedure. Goitrin is a moderate inhibitor of purified bovine adrenal dopamine beta-hydroxylase. The administration of goitrin leads to a depression of brain norepinephrine and to an elevation of heart and adrenal dopamine.
摘要
Zotero 插件