Batista Joanna d'Arc Lyra, Albuquerque Maria de Fátima Pessoa Militão de, Santos Marcela Lopes, Miranda-Filho Demócrito de Barros, Lacerda Heloísa Ramos, Maruza Magda, Moura Libia Vilela, Coimbra Isabella, Ximenes Ricardo Arraes de Alencar
Universidade Federal de Pernambuco, RecifePernambuco, Brazil, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Centro de Pesquisas Aggeu Magalhães/FIOCRUZ, RecifePernambuco, Brazil, Centro de Pesquisas Aggeu Magalhães/FIOCRUZ, Recife, Pernambuco, Brazil.
Rev Inst Med Trop Sao Paulo. 2014 Mar-Apr;56(2):127-32. doi: 10.1590/S0036-46652014000200007.
Despite the effectiveness of combination antiretroviral therapy in the treatment of people living with HIV/AIDS (PLWHA), nonadherence to medication has become a major threat to its effectiveness. This study aimed to estimate the prevalence of self-reported irregular use of antiretroviral therapy and the factors associated with such an irregularity in PLWHA. A cross-sectional study of PLWHA who attended two referral centers in the city of Recife, in Northeastern Brazil, between June 2007 and October 2009 was carried out. The study analyzed socioeconomic factors, social service support and personal habits associated with nonadherence to antiretroviral therapy, adjusted by multivariable logistic regression analysis. The prevalence of PLWHA who reported irregular use of combination antiretroviral therapy (cART) was 25.7%. In the final multivariate model, the irregular use of cART was associated with the following variables: being aged less than 40 years (OR = 1.66, 95%-CI: 1.29-2.13), current smokers (OR = 1.76, 95%-CI: 1.31-2.37) or former smokers (OR = 1.43, 95%-CI: 1.05-1.95), and crack cocaine users (OR = 2.79, 95%-CI: 1.24-6.32). Special measures should be directed towards each of the following groups: individuals aged less than 40 years, smokers, former smokers and crack cocaine users. Measures for giving up smoking and crack cocaine should be incorporated into HIV-control programs in order to promote greater adherence to antiretroviral drugs and thus improve the quality of life and prolong life expectancy.
尽管联合抗逆转录病毒疗法在治疗艾滋病毒/艾滋病患者方面具有有效性，但不坚持服药已成为其有效性的一大威胁。本研究旨在估计自我报告的抗逆转录病毒疗法不规则使用情况的患病率，以及与艾滋病毒/艾滋病患者这种不规则使用相关的因素。对2007年6月至2009年10月期间在巴西东北部累西腓市两个转诊中心就诊的艾滋病毒/艾滋病患者进行了一项横断面研究。该研究分析了与不坚持抗逆转录病毒疗法相关的社会经济因素、社会服务支持和个人习惯，并通过多变量逻辑回归分析进行了调整。报告联合抗逆转录病毒疗法（cART）不规则使用的艾滋病毒/艾滋病患者的患病率为25.7%。在最终的多变量模型中，cART的不规则使用与以下变量相关：年龄小于40岁（OR = 1.66，95%置信区间：1.29 - 2.13）、当前吸烟者（OR = 1.76，95%置信区间：1.31 - 2.37）或既往吸烟者（OR = 1.43，95%置信区间：1.05 - 1.95）以及快克可卡因使用者（OR = 2.79，95%置信区间：1.24 - 6.32）。应针对以下每组人群采取特别措施：年龄小于40岁的个体、吸烟者、既往吸烟者和快克可卡因使用者。应将戒烟和戒除快克可卡因的措施纳入艾滋病毒控制项目，以促进对抗逆转录病毒药物的更大坚持，从而提高生活质量并延长预期寿命。
