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人类细胞分裂周期蛋白2（cdc2）蛋白激酶是一种主要受细胞周期调控的酪氨酸激酶底物。

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate.

作者信息

Draetta G, Piwnica-Worms H, Morrison D, Druker B, Roberts T, Beach D

机构信息

Cold Spring Harbor Laboratory, New York 11724.

出版信息

Nature. 1988;336(6201):738-44. doi: 10.1038/336738a0.

DOI:10.1038/336738a0
PMID:2462672
Abstract

cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site of cdc2 tyrosine phosphorylation in vivo is selectively phosphorylated by pp60c-src in vitro.

摘要

细胞周期蛋白依赖性激酶2（cdc2）是一种蛋白激酶复合物的催化亚基，该复合物称为M期促进因子，可诱导细胞进入有丝分裂，在真核生物中普遍存在。在HeLa细胞中，cdc2被证明是含量最丰富的含磷酸酪氨酸的蛋白，其磷酸酪氨酸含量受细胞周期调控。cdc2在体内的一个酪氨酸磷酸化位点在体外可被pp60c-src选择性磷酸化。

相似文献

1
Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate.人类细胞分裂周期蛋白2（cdc2）蛋白激酶是一种主要受细胞周期调控的酪氨酸激酶底物。
Nature. 1988;336(6201):738-44. doi: 10.1038/336738a0.
2
p34cdc2 is physically associated with and phosphorylated by a cdc2-specific tyrosine kinase.p34cdc2与一种cdc2特异性酪氨酸激酶在物理上相关联并被其磷酸化。
Cell Growth Differ. 1991 Jul;2(7):343-9.
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Most of the substrates of oncogenic viral tyrosine protein kinases can be phosphorylated by cellular tyrosine protein kinases in normal cells.致癌病毒酪氨酸蛋白激酶的大多数底物在正常细胞中可被细胞酪氨酸蛋白激酶磷酸化。
Oncogene Res. 1988 Sep;3(2):105-15.
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Regulation of the cellular src protein tyrosine kinase: interactions of the carboxyl terminal sequences residing between the kinase domain and tyrosine-527.细胞源蛋白酪氨酸激酶的调控：激酶结构域与酪氨酸-527之间羧基末端序列的相互作用
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Avian pp60c-src is more active when expressed in yeast than in vertebrate fibroblasts.禽源pp60c-src在酵母中表达时比在脊椎动物成纤维细胞中更具活性。
Oncogene Res. 1987 Sep-Oct;1(4):297-310.
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Myristylation and amino-terminal phosphorylation are required for activation of pp60c-src during mitosis.在有丝分裂过程中，pp60c-src的激活需要肉豆蔻酰化和氨基末端磷酸化。
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Novel tyrosine phosphorylations accompany the activation of pp60c-src during chemical carcinogenesis.在化学致癌过程中，新的酪氨酸磷酸化伴随着pp60c-src的激活。
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Synaptophysin: a substrate for the protein tyrosine kinase pp60c-src in intact synaptic vesicles.突触素：完整突触小泡中蛋白酪氨酸激酶pp60c-src的一种底物。
Oncogene. 1990 Jul;5(7):1019-24.
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cdc2/pp56-62 are in vitro substrates for the tyrosine kinase encoded by the v-fms oncogene.
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Increased levels of p21ras-GTP and enhanced DNA synthesis accompany elevated tyrosyl phosphorylation of GAP-associated proteins, p190 and p62, in c-src overexpressors.在c-src过表达细胞中，p21ras-GTP水平升高以及DNA合成增强，同时GAP相关蛋白p190和p62的酪氨酰磷酸化增强。
Oncogene. 1993 Apr;8(4):959-67.

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