Department of Paediatric Haematology and Oncology Research, National Research Institute for Child Health and Development, Tokyo, Japan.
Br J Haematol. 2014 Jun;165(6):836-41. doi: 10.1111/bjh.12834. Epub 2014 Mar 15.
We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.
我们鉴定出 ATF7IP 是 B 祖细胞急性淋巴细胞白血病（B-ALL）中的一种新型 PDGFRB 融合伙伴，并表明具有 ATF7IP/PDGFRB 易位的 B-ALL 包含在费城染色体（Ph）样 ALL 亚组的基因组病变内。对先前基因表达数据集存储库的综合分析表明，在 Ph 样 ALL 基因的背景下具有高 PDGFRB 表达水平的 B-ALL 病例可能具有 PDGFRB 易位。因此，测量 PDGFRB 的表达水平可能可作为检测隐匿性 PDGFRB 易位的筛选试验，尤其是在 Ph 样 ALL 亚组内。
