Dorval T, Pouillart P
Service de médecine oncologique, Institut Curie, Paris, France.
Bull Cancer. 1988;75(9):885-8.
A potential activity of interferons in the treatment of solid tumors has been suggested by in vitro experiments and, more recently, by phase I trials. Phase II trials have demonstrated a possible antitumoral activity in treating some solid tumors: malignant melanoma, renal cell carcinoma, ovarian adenocarcinoma, carcinoid tumor, superficial bladder cancer. Further trials are necessary to establish the precise role of interferons in treating solid tumors, when administered alone or in combination.
体外实验,以及最近的I期试验均表明,干扰素在实体瘤治疗中具有潜在活性。II期试验已证明,干扰素在治疗某些实体瘤时可能具有抗肿瘤活性,这些实体瘤包括:恶性黑色素瘤、肾细胞癌、卵巢腺癌、类癌肿瘤、浅表性膀胱癌。单独或联合使用干扰素治疗实体瘤时,有必要开展进一步试验以明确其确切作用。