Department of Emergency Medicine, University of Connecticut, Hartford Hospital, Hartford, CT.
Yale University School of Medicine, New Haven, CT.
Ann Emerg Med. 2014 Sep;64(3):269-76. doi: 10.1016/j.annemergmed.2014.01.012. Epub 2014 Mar 11.
Hydronephrosis is readily visible on ultrasonography and is a strong predictor of ureteral stones, but ultrasonography is a user-dependent technology and the test characteristics of clinician-performed ultrasonography for hydronephrosis are incompletely characterized, as is the effect of ultrasound fellowship training on predictive accuracy. We seek to determine the test characteristics of ultrasonography for detecting hydronephrosis when performed by clinicians with a wide range of experience under conditions of direct patient care.
This was a prospective study of patients presenting to an academic medical center emergency department with suspected renal colic. Before computed tomography (CT) results, an emergency clinician performed bedside ultrasonography, recording the presence and degree of hydronephrosis. CT data were abstracted from the dictated radiology report by an investigator blinded to the bedside ultrasonographic results. Test characteristics of bedside ultrasonography for hydronephrosis were calculated with the CT scan as the reference standard, with test characteristics compared by clinician experience stratified into 4 levels: attending physicians with emergency ultrasound fellowship training, attending physicians without emergency ultrasound fellowship training, ultrasound experienced non-attending physician clinicians (at least 2 weeks of ultrasound training), and ultrasound inexperienced non-attending physician clinicians (physician assistants, nurse practitioners, off-service rotators, and first-year emergency medicine residents with fewer than 2 weeks of ultrasound training).
There were 670 interpretable bedside ultrasonographic tests performed by 144 unique clinicians, 80.9% of which were performed by clinicians directly involved in the care of the patient. On CT, 47.5% of all subjects had hydronephrosis and 47.0% had a ureteral stone. Among all clinicians, ultrasonography had a sensitivity of 72.6% (95% confidence interval [CI] 65.4% to 78.9%), specificity of 73.3% (95% CI 66.1% to 79.4%), positive likelihood ratio of 2.72 (95% CI 2.25 to 3.27), and negative likelihood ratio of 0.37 (95% CI 0.31 to 0.44) for hydronephrosis, using hydronephrosis on CT as the criterion standard. Among attending physicians with fellowship training, ultrasonography had sensitivity of 92.7% (95% CI 83.8% to 96.9%), positive likelihood ratio of 4.97 (95% CI 2.90 to 8.51), and negative likelihood ratio of 0.08 (95% CI 0.03 to 0.23).
Overall, ultrasonography performed by emergency clinicians was moderately sensitive and specific for detection of hydronephrosis as seen on CT in patients with suspected renal colic. However, presence or absence of hydronephrosis as determined by emergency physicians with fellowship training in ultrasonography yielded more definitive test results. For clinicians without fellowship training, there was no significant difference between groups in the predictive accuracy of the application according to experience level.
超声检查很容易发现肾积水,并且是输尿管结石的强烈预测指标,但超声检查是一种依赖于用户的技术,并且尚未充分描述临床医生进行的超声检查肾积水的测试特征,超声研究金标准培训对预测准确性的影响也是如此。我们旨在确定在直接患者护理条件下,具有广泛经验的临床医生进行超声检查检测肾积水的测试特征。
这是一项对在学术医疗中心急诊科就诊的疑似肾绞痛患者进行的前瞻性研究。在 CT 结果之前,急诊临床医生进行了床边超声检查,记录了肾积水的存在和程度。CT 数据由一名对床边超声检查结果一无所知的研究人员从口述放射学报告中提取。将 CT 扫描作为参考标准计算床边超声检查肾积水的测试特征,并根据临床医生的经验将测试特征分层为 4 个级别进行比较:具有急诊超声研究金标准培训的主治医生、没有急诊超声研究金标准培训的主治医生、具有超声经验的非主治医生临床医生(至少 2 周的超声培训)和缺乏超声经验的非主治医生临床医生(医师助理、执业护士、轮换医生和第一年内科住院医师,超声培训不足 2 周)。
有 144 名不同的临床医生进行了 670 次可解释的床边超声检查,其中 80.9%的超声检查是由直接参与患者护理的医生进行的。在 CT 上,所有患者中有 47.5%存在肾积水,47.0%有输尿管结石。在所有临床医生中,超声检查的敏感度为 72.6%(95%置信区间[CI]65.4%至 78.9%),特异性为 73.3%(95%CI 66.1%至 79.4%),阳性似然比为 2.72(95%CI 2.25 至 3.27),阴性似然比为 0.37(95%CI 0.31 至 0.44),以 CT 上的肾积水为标准。在具有研究金标准培训的主治医生中,超声检查的敏感度为 92.7%(95%CI 83.8%至 96.9%),阳性似然比为 4.97(95%CI 2.90 至 8.51),阴性似然比为 0.08(95%CI 0.03 至 0.23)。
总体而言,在疑似肾绞痛患者中,急诊临床医生进行的超声检查对 CT 上肾积水的检测具有中等的敏感性和特异性。然而,具有超声研究金标准培训的急诊医生确定的肾积水的存在或不存在,其检测结果更明确。对于没有研究金标准培训的医生,根据经验水平,该应用的预测准确性在不同组之间没有显著差异。