储存肾上腺素和去甲肾上腺素的肾上腺髓质细胞的分泌受一种常见的二氢吡啶敏感钙通道调节。

Secretion from adrenaline- and noradrenaline-storing adrenomedullary cells is regulated by a common dihydropyridine-sensitive calcium channel.

作者信息

Cárdenas A M, Montiel C, Esteban C, Borges R, García A G

机构信息

Department of Pharmacology, Universidad Autónoma de Madrid, Facultad de Medicina, Spain.

出版信息

Brain Res. 1988 Jul 26;456(2):364-6. doi: 10.1016/0006-8993(88)90240-5.

DOI:10.1016/0006-8993(88)90240-5

PMID:2463038

Abstract

Dihydropyridines (+)-PN200-110 and (+/-)-Bay-K-8644 inhibit or potentiate, respectively, catecholamine release evoked by DMPP- or K-stimulation of perfused cat adrenal glands. Since both, secretion of adrenaline and noradrenaline are equally affected, and these two drugs specifically act on voltage-dependent chromaffin Ca channels, it seems that secretion of each amine from their respective cell is regulated by the same type of channel.

摘要

二氢吡啶类化合物（+）-PN200-110和（±）-Bay-K-8644分别抑制或增强了灌注猫肾上腺经DMPP或钾刺激诱发的儿茶酚胺释放。由于肾上腺素和去甲肾上腺素的分泌均受到同等影响，且这两种药物特异性作用于电压依赖性嗜铬细胞钙通道，因此似乎每种胺从其各自细胞的分泌是由同一类型的通道调节的。