快照：桩蛋白和整合素黏着斑的模块化性质。
SnapShot: talin and the modular nature of the integrin adhesome.
机构信息
Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
出版信息
Cell. 2014 Mar 13;156(6):1340-1340.e1. doi: 10.1016/j.cell.2014.02.048.
Abstract
Integrin αβ transmembrane heterodimers play central roles in metazoan development and physiology by mediating adhesion and by transmitting forces and biochemical signals across the plasma membrane. In this SnapShot, we present a simplified "modular" view of the integrin adhesome, centered on the talin-integrin interaction, and provide examples of how this view can help to unravel the adhesome's remarkable functional diversity and plasticity.
摘要
整合素 αβ 跨膜异二聚体通过介导黏附以及在质膜两侧传递力和生化信号，在后生动物的发育和生理过程中发挥核心作用。在这个 SnapShot 中，我们提出了一个简化的“模块化”整合素黏着斑视图，以 talin-整合素相互作用为中心，并提供了一些示例，说明如何利用这种观点来揭示黏着斑的显著功能多样性和可塑性。
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