Schwarz N, Redl H, Schlag G, Schiesser A, Lintner F, Dinges H P, Thurnher M
Ludwig Boltzmann Institute for Experimental Traumatology, Vienna, Austria.
Clin Orthop Relat Res. 1989 Jan(238):282-7.
Allogeneic demineralized bone matrix (DBM) and bone matrix gelatin (BMG) were implanted with or without fibrin sealant (FS) ectopically (abdominal wall) and orthotopically (7-mm trepanation defect) in 38 male Sprague-Dawley rats. Evaluation was done by descriptive histology, histomorphometry of orthotopic implants, and determination of alkaline phosphatase in ectopic implants. The observation period was 21 days with ectopic implantation and 26 days with orthotopic implantation. In all ectopic specimens, new bone developed without any qualitative difference between specimens with and without FS. The alkaline phosphatase activity did not change significantly upon addition of FS. Morphometry revealed slight differences between the groups with and without FS. The peripheral bone deposits in the BMG + FS group, was significantly larger than in the BMG group. These investigations demonstrated neither a clearly positive nor negative effect of FS on ectopic osteoinduction or BMG-dependent osteoregeneration.
将同种异体脱矿骨基质（DBM）和骨基质明胶（BMG）分别在有或没有纤维蛋白密封剂（FS）的情况下，异位（腹壁）和原位（7毫米环钻缺损）植入38只雄性Sprague-Dawley大鼠体内。通过描述性组织学、原位植入物的组织形态计量学以及异位植入物中碱性磷酸酶的测定进行评估。异位植入的观察期为21天，原位植入的观察期为26天。在所有异位标本中，均有新骨形成，添加FS和未添加FS的标本之间没有任何质量差异。添加FS后，碱性磷酸酶活性没有显著变化。形态计量学显示添加FS和未添加FS的组之间存在细微差异。BMG + FS组的周边骨沉积明显大于BMG组。这些研究表明，FS对异位骨诱导或BMG依赖性骨再生既没有明显的积极作用，也没有明显的消极作用。
