Sohmer H, Gold S, Cahani M, Attias J
Dept. of Physiology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Electroencephalogr Clin Neurophysiol. 1989 Jan-Feb;74(1):50-7. doi: 10.1016/0168-5597(89)90051-8.
Auditory nerve brain-stem (ABR) and somatosensory evoked responses (SER) were recorded in cats as body temperature was uniformly lowered from 37 to 27 degrees C. Analysis of the results showed that the alterations in the evoked responses were due to disturbances induced both in axonal propagation and synaptic transmission by the hypothermia. By studying the first wave of the SER, which is solely an axonal event, and by assuming reasonable values for the total synaptic delay and axonal propagation times along the ABR pathway, it was concluded that this lesion model induced an effect on synaptic transmission 1.3-1.7 times greater than that on axonal propagation. There was a strong inverse correlation between wave latency and body temperature, with slightly steeper slopes for the longer latency waves. Wave amplitudes were not correlated with temperature. Furthermore, the wave latencies and amplitudes were generally not dependent on stimulus rate.
在猫身上记录听觉神经脑干（ABR）和体感诱发电位（SER），同时将体温从37℃均匀降至27℃。结果分析表明，诱发电位的改变是由于体温过低引起的轴突传导和突触传递紊乱所致。通过研究仅为轴突事件的SER的第一波，并假设沿ABR通路的总突触延迟和轴突传导时间的合理值，得出该损伤模型对突触传递的影响比对轴突传导的影响大1.3 - 1.7倍。波潜伏期与体温之间存在很强的负相关，潜伏期较长的波斜率略陡。波幅与温度无关。此外，波潜伏期和波幅通常不依赖于刺激频率。
