Borrell Víctor, Götz Magdalena
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain.
Institute of Stem Cell Research, German Research Center for Environmental Health, Helmholtz Center Munich, 85764 Neuherberg, Germany; Physiological Genomics, Ludwig Maximilians University, 80336 Munich, Germany.
Curr Opin Neurobiol. 2014 Aug;27:39-46. doi: 10.1016/j.conb.2014.02.007. Epub 2014 Mar 12.
Radial glial cells play key roles during cerebral cortex development, as primary stem and progenitor cells giving rise-directly or indirectly-to neurons and glia, but also acting as scaffold for the cerebral cortex architecture and migrating neurons. Recent work led to the discovery of novel types of radial glial cells with key roles in gyrification, the folding of the mammalian cerebral cortex in phylogeny and ontogeny. Here we summarize the cellular and molecular basis of this fascinating process allowing the expansion of the mammalian cerebral cortex with all its functional consequences.
放射状胶质细胞在大脑皮层发育过程中发挥着关键作用，它们作为主要的干细胞和祖细胞，直接或间接地产生神经元和神经胶质细胞，同时还为大脑皮层结构和迁移的神经元提供支架。最近的研究发现了新型放射状胶质细胞，它们在脑回形成过程中起着关键作用，脑回形成是指哺乳动物大脑皮层在系统发育和个体发育过程中的折叠。在这里，我们总结了这一迷人过程的细胞和分子基础，这一过程使得哺乳动物大脑皮层得以扩展并产生所有的功能结果。
