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Imatinib mesylate (Gleevec, Glivec): a new therapy for chronic myeloid leukemia and other malignancies.甲磺酸伊马替尼（格列卫）：一种治疗慢性粒细胞白血病及其他恶性肿瘤的新疗法。
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Co-Occurrence of Jak2-Positive Myelofibrosis and Bcr-Abl-Positive Chronic Myelogenous Leukaemia Treated with Combination of Tyrosine Kinase Inhibitors and Ruxolitinib.酪氨酸激酶抑制剂与芦可替尼联合治疗 Jak2 阳性骨髓纤维化和 Bcr-Abl 阳性慢性粒细胞白血病并存的情况
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Coexistence of -positive chronic myeloid leukemia and -mutated myelofibrosis successfully treated with dasatinib and ruxolitinib.携带 BCR-ABL 阳性的慢性粒细胞白血病与 JAK2 突变的骨髓纤维化共存，经达沙替尼和芦可替尼成功治疗。 （注：原文中存在信息缺失，推测完整内容可能是这样，仅供参考，具体需结合完整原文准确翻译。这里按照推测补充了BCR-ABL和JAK2，以使译文完整通顺。）
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A Case of Chronic Myelogenous Leukemia Occurring in a Patient Treated for Essential Thrombocythemia.一例发生于原发性血小板增多症治疗患者的慢性粒细胞白血病病例。
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Treatment of Myelofibrosis: Old and New Strategies.骨髓纤维化的治疗：新旧策略
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Ruxolitinib improves symptoms and quality of life in a patient with systemic mastocytosis.芦可替尼可改善系统性肥大细胞增多症患者的症状和生活质量。
Biomark Res. 2016 Feb 5;4:2. doi: 10.1186/s40364-016-0056-5. eCollection 2016.
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Concomitant JAK2 V617F-positive polycythemia vera and BCR-ABL-positive chronic myelogenous leukemia treated with ruxolitinib and dasatinib.用芦可替尼和达沙替尼治疗的JAK2 V617F阳性真性红细胞增多症与BCR-ABL阳性慢性粒细胞白血病并存病例
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本文引用的文献

1
Selective strong synergism of Ruxolitinib and second generation tyrosine kinase inhibitors to overcome bone marrow stroma related drug resistance in chronic myelogenous leukemia.芦可替尼与第二代酪氨酸激酶抑制剂的选择性强强协同作用，克服慢性髓性白血病中骨髓基质相关的药物耐药性。
Leuk Res. 2014 Feb;38(2):236-42. doi: 10.1016/j.leukres.2013.11.006. Epub 2013 Nov 15.
2
Advances in myelofibrosis: a clinical case approach.骨髓纤维化的进展：临床病例分析。
Haematologica. 2013 Oct;98(10):1499-509. doi: 10.3324/haematol.2013.086348.
3
Resolution of bone marrow fibrosis in a patient receiving JAK1/JAK2 inhibitor treatment with ruxolitinib.接受芦可替尼治疗的 JAK1/JAK2 抑制剂治疗患者的骨髓纤维化缓解。
Haematologica. 2013 Dec;98(12):1872-6. doi: 10.3324/haematol.2013.095109. Epub 2013 Sep 20.
4
Comparison of placebo and best available therapy for the treatment of myelofibrosis in the phase 3 COMFORT studies.3 期 COMFORT 研究中安慰剂和最佳可用疗法治疗骨髓纤维化的比较。
Haematologica. 2014 Feb;99(2):292-8. doi: 10.3324/haematol.2013.087650. Epub 2013 Aug 2.
5
Ruxolitinib: a potent and selective Janus kinase 1 and 2 inhibitor in patients with myelofibrosis. An update for clinicians.芦可替尼：治疗骨髓纤维化患者的一种有效且选择性的 Janus 激酶 1 和 2 抑制剂。临床医生的最新资讯。
Ther Adv Hematol. 2012 Dec;3(6):341-54. doi: 10.1177/2040620712459746.
6
Effect of ruxolitinib therapy on myelofibrosis-related symptoms and other patient-reported outcomes in COMFORT-I: a randomized, double-blind, placebo-controlled trial.芦可替尼治疗对 COMFORT-I 研究中骨髓纤维化相关症状和其他患者报告结局的影响：一项随机、双盲、安慰剂对照试验。
J Clin Oncol. 2013 Apr 1;31(10):1285-92. doi: 10.1200/JCO.2012.44.4489. Epub 2013 Feb 19.
7
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis.芦可替尼与最佳可用疗法治疗骨髓纤维化的 JAK 抑制作用比较。
N Engl J Med. 2012 Mar 1;366(9):787-98. doi: 10.1056/NEJMoa1110556.
8
Long-term outcome of treatment with ruxolitinib in myelofibrosis.芦可替尼治疗骨髓纤维化的长期疗效
N Engl J Med. 2011 Oct 13;365(15):1455-7. doi: 10.1056/NEJMc1109555.
9
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis.INCB018424，一种 JAK1 和 JAK2 抑制剂，在骨髓纤维化中的安全性和疗效。
N Engl J Med. 2010 Sep 16;363(12):1117-27. doi: 10.1056/NEJMoa1002028.
10
New prognostic scoring system for primary myelofibrosis based on a study of the International Working Group for Myelofibrosis Research and Treatment.基于骨髓纤维化研究与治疗国际工作组的一项研究的原发性骨髓纤维化新预后评分系统。
Blood. 2009 Mar 26;113(13):2895-901. doi: 10.1182/blood-2008-07-170449. Epub 2008 Nov 6.

Imatinib and ruxolitinib association: first experience in two patients.

作者信息

Iurlo Alessandra, Gianelli Umberto, Rapezzi Davide, Cattaneo Daniele, Fermo Elisa, Binda Francesca, Santambrogio Elisa, Bucelli Cristina, Cortelezzi Agostino

机构信息

Oncohematology Unit of the Elderly, Oncohematology Division, IRCCS Ca' Granda - Maggiore Policlinico Hospital Foundation, and University of Milan Medical School, Milan, Italy Hematopathology Service, Division of Pathology, IRCCS Ca' Granda - Maggiore Policlinico Hospital Foundation, and University of Milan Medical School, Milan, Italy Division of Hematology, Santa Croce e Carle Hospital, Cuneo, Italy Oncohematology Division, IRCCS Ca' Granda - Maggiore Policlinico Hospital Foundation, and University of Milan Medical School, Italy

Hematopathology Service, Division of Pathology, IRCCS Ca' Granda - Maggiore Policlinico Hospital Foundation, and University of Milan Medical School, Milan, Italy.

出版信息

Haematologica. 2014 Jun;99(6):e76-7. doi: 10.3324/haematol.2013.102525. Epub 2014 Mar 14.

DOI:10.3324/haematol.2013.102525
PMID:24633869
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4040897/
Abstract
摘要