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盐酸去氢吴茱萸碱改善应激诱导的大鼠记忆损伤和抑郁样行为。

Dehydroevodiamine·HCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats.

机构信息

Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799, Korea. ; Korea Brain Research Institute (KBRI), Daegu 700-010, Korea.

Department of Pharmacology, College of Medicine, Seoul National University, Seoul 110-799, Korea. ; Braintropia Co. Ltd., Anyang 431-716, Korea.

出版信息

Korean J Physiol Pharmacol. 2014 Feb;18(1):55-9. doi: 10.4196/kjpp.2014.18.1.55. Epub 2014 Feb 13.

DOI:10.4196/kjpp.2014.18.1.55
PMID:24634597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3951824/
Abstract

Dehydroevodiamine·HCl (DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress. We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability. Our results suggested that DHED is a potential drug candidate for neuronal death, memory impairment and depression induced by stress.

摘要

盐酸去氢吴茱萸碱（DHED）已被报道可预防认知障碍大鼠模型中的记忆障碍和神经元细胞丢失。我们研究了 DHED 对应激引起的记忆障碍和行为异常的影响。通过使用旷场试验、Y 迷宫试验和强迫游泳试验，我们证明 DHED 可以改善应激引起的记忆障碍和抑郁样行为。DHED 治疗显著恢复了应激引起的神经细胞黏附分子（NCAM）蛋白水平下降和细胞活力下降。我们的结果表明，DHED 是一种潜在的药物候选物，可用于治疗应激引起的神经元死亡、记忆障碍和抑郁。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0f6/3951824/114653aa6361/kjpp-18-55-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0f6/3951824/c2b0b3d7f30e/kjpp-18-55-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0f6/3951824/2fe1e0ab8eaf/kjpp-18-55-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0f6/3951824/114653aa6361/kjpp-18-55-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0f6/3951824/c2b0b3d7f30e/kjpp-18-55-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0f6/3951824/2fe1e0ab8eaf/kjpp-18-55-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f0f6/3951824/114653aa6361/kjpp-18-55-g003.jpg

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