Treglia Giorgio, Ceriani Luca, Giovanella Luca
Department of Nuclear Medicine and PET/CT Center, Ente Ospedaliero Cantonale, via Ospedale, 12; zip code: 6500; Bellinzona, Switzerland.
Curr Radiopharm. 2014;7(1):75-8. doi: 10.2174/1874471007666140314094323.
Dementia with Lewy bodies (DLB) is the second most common cause of degenerative dementia after Alzheimer's disease (AD). To improve the diagnosis of DLB, the latest diagnostic criteria incorporate findings from neuroimaging studies including sympathetic innervation imaging with iodine-123-metaiodobenzylguanidine (MIBG). According to these criteria a decreased MIBG myocardial uptake is an important finding supporting a clinical diagnosis of DLB. In this review the state of art and future perspectives of sympathetic innervation imaging by using MIBG in the diagnosis of DLB are discussed.
路易体痴呆（DLB）是继阿尔茨海默病（AD）之后第二常见的退行性痴呆病因。为改善DLB的诊断，最新诊断标准纳入了神经影像学研究结果，包括使用碘-123-间碘苄胍（MIBG）进行的交感神经支配成像。根据这些标准，MIBG心肌摄取减少是支持DLB临床诊断的一项重要发现。在本综述中，将讨论使用MIBG进行交感神经支配成像在DLB诊断中的现状和未来前景。
