Bartáková A, Pecková K, Daum O, Bouda J
Ceska Gynekol. 2014 Jan;79(1):7-11.
Detection of cancer stem cells (CSCs) in ovarian cancer, influence of CSCs on overall survival, disease free interval. Results in comparison with literature.
Original study.
Department of Gynaecology and Obstetrics, Faculty Hospital Pilsen and Medical Faculty in Pilsen, Charles University, Šikls Institute of Pathology, Faculty Hospital Pilsen and Medical Faculty in Pilsen, Charles University.
23 specimens of papillary-serous ovarian carcinoma and 4 specimens of endometroid ovarian carcinoma were included in the study. Specific antibodies to CD44 and CD133 antigens were used. Immunoreaction of both CD44 and CD133 was evaluated for the high power field.
There was no significant correlation between CD44 expression and disease free interval and overall survival. CD133 expression was not evaluated due to an inadequate immunoreaction antibody - antigene.
We did not find any statistically correlation between CD44 expression and overall survival and disease free interval in our series of patients with ovarian carcinoma. It seems to be better to use different antibody for CD133 detection.
检测卵巢癌中的癌症干细胞（CSCs），CSCs对总生存期、无病生存期的影响。结果与文献比较。
原创性研究。
比尔森大学医院妇产科、比尔森医学院、查尔斯大学、比尔森大学医院Šikls病理研究所、比尔森医学院、查尔斯大学。
本研究纳入23例乳头状浆液性卵巢癌标本和4例子宫内膜样卵巢癌标本。使用针对CD44和CD133抗原的特异性抗体。在高倍视野下评估CD44和CD133的免疫反应。
CD44表达与无病生存期和总生存期之间无显著相关性。由于免疫反应抗体-抗原不足，未评估CD133表达。
在我们的卵巢癌患者系列中，未发现CD44表达与总生存期和无病生存期之间存在任何统计学相关性。似乎最好使用不同的抗体来检测CD133。
