MECP2 兼职充当 microRNA 加工的抑制剂。
MeCP2 caught moonlighting as a suppressor of MicroRNA processing.
机构信息
Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.
Center for RNA Research, Institute for Basic Science, Seoul 151-742, Korea; School of Biological Sciences, Seoul National University, Seoul 151-742, Korea.
出版信息
Dev Cell. 2014 Mar 10;28(5):477-8. doi: 10.1016/j.devcel.2014.02.015.
MeCP2 is a transcriptional regulator important for neurodevelopment and is involved in Rett syndrome and autism. In this issue of Developmental Cell, Cheng and colleagues (2014) report that MeCP2 also regulates microRNA biogenesis. MeCP2 phosphorylation induces a direct interaction with DGCR8, leading to reduced microRNA processing and retardation of dendritic growth.
MECP2 是一种对神经发育很重要的转录调控因子，与雷特综合征和自闭症有关。在本期《发育细胞》中，Cheng 及其同事（2014）报告称，MECP2 还调节 microRNA 的生物发生。MECP2 的磷酸化诱导与 DGCR8 的直接相互作用，导致 microRNA 加工减少和树突生长迟缓。
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