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安非他酮过量中毒的血液灌流治疗

Charcoal hemoperfusion in bupropion overdose.

作者信息

Akdemir Hızır Ufuk, Calışkan Fatih, Duran Latif, Katı Celal, Güngörer Bülent, Ocak Metin

机构信息

Department of Emergency Medicine, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.

Department of Emergency Medicine, Ondokuz Mayis University, Faculty of Medicine, Samsun, Turkey.

出版信息

J Formos Med Assoc. 2014 Oct;113(10):754-5. doi: 10.1016/j.jfma.2014.01.019. Epub 2014 Mar 11.

Abstract

Bupropion is a relatively new and popular medication for depression, with seizures as its major side effect. In the literature, there are insufficient data about hemodialysis following bupropion overdose. A 23-year-old female patient was brought to our emergency department with acute change in mental status and seizure after deliberate self-poisoning with approximately 25-30 tablets of bupropion hydrochloride. Her Glasgow coma scale score was 8/15. The patient underwent hemodialysis about 4 hours later. After 4 hours of extracorporeal treatment, she became conscious and was extubated. We present a case of full recovery after charcoal hemoperfusion following a bupropion overdose.

摘要

安非他酮是一种相对较新且常用的抗抑郁药物,癫痫发作是其主要副作用。在文献中,关于安非他酮过量后血液透析的数据不足。一名23岁女性患者因故意自服约25 - 30片盐酸安非他酮后出现精神状态急性改变和癫痫发作,被送至我院急诊科。她的格拉斯哥昏迷量表评分为8/15。患者约4小时后接受了血液透析。经过4小时的体外治疗后,她恢复意识并拔除了气管插管。我们报告一例安非他酮过量后经活性炭血液灌流完全康复的病例。

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