A型肉毒毒素对参加康复计划的中风后患者足部痉挛的影响。
Effects of botulinum toxin type A for spastic foot in post-stroke patients enrolled in a rehabilitation program.
作者信息
Pimentel Leonardo Halley Carvalho, Alencar Francisco José, Rodrigues Leonardo Raphael Santos, Sousa Francisca Cléa Florenço de, Teles João Batista Mendes
机构信息
Centro Integrado de Reabilitação, TeresinaPI, Brazil.
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, FortalezaCE, Brazil.
出版信息
Arq Neuropsiquiatr. 2014 Jan;72(1):28-32. doi: 10.1590/0004-282X20130189.
UNLABELLED
The objective of this study was to evaluate the effects of botulinum toxin type A (BTX-A) on spastic foot in stroke patients in a rehabilitation program.
METHOD
Hemiparetic stroke patients (n=21) enrolled in a rehabilitation program were divided into two groups. The first group (n=11) received a total of 300 UI BTX-A, and the second group (n=10) received 100 UI BTX-A. All patients were assessed at baseline and 2, 4, 8 and 12 weeks after injection for Modified Ashworth Score, time walking 10 meters, and the Functional Independence Measure (mFIM) motor score.
RESULTS
The higher-dose group exhibited a significant improvement in spasticity, and both groups showed an improvement in time walking 10 meters and mFIM, with no significant differences between them.
CONCLUSIONS
Our findings suggest that gains in gait velocity and functional independence were not correlated to BTX-A dose.
未标注
本研究的目的是评估A型肉毒毒素（BTX-A）在康复计划中对中风患者痉挛性足的影响。
方法
纳入康复计划的偏瘫中风患者（n = 21）分为两组。第一组（n = 11）共接受300单位BTX-A，第二组（n = 10）接受100单位BTX-A。所有患者在基线时以及注射后2、4、8和12周进行评估，评估指标包括改良Ashworth评分、10米步行时间以及功能独立性测量（mFIM）运动评分。
结果
高剂量组的痉挛状况有显著改善，两组在10米步行时间和mFIM方面均有改善，但两组之间无显著差异。
结论
我们的研究结果表明，步态速度和功能独立性的改善与BTX-A剂量无关。
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