Department of Anaesthesia and Intensive Care, University of Torino, Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, Presidio Molinette, Corso Dogliotti 14, 10126 Torino, Italy.
Br J Anaesth. 2014 May;112(5):803-15. doi: 10.1093/bja/aeu046. Epub 2014 Mar 17.
Neurogenic stress cardiomyopathy (NSC) is a well-known syndrome complicating the early phase after an acute brain injury, potentially affecting outcomes. This article is a review of recent data on the putative role of localization and lateralization of brain lesions in NSC, cardiac innervation abnormalities, and new polymorphisms and other genetic causes of the sympathetic nervous system over-activity. Concerns regarding the management of stress-related cardiomyopathy syndromes during the perioperative period are also discussed. Future clinical research should explore whether specific factors explain different patient susceptibilities to the disease and should be directed towards early identification and stratification of patients at risk, so that such patients can be more carefully monitored and appropriately managed in critical care and during the perioperative period.
神经源性应激性心肌病（NSC）是一种众所周知的综合征，常发生于急性脑损伤的早期，可能会影响预后。本文综述了最近关于脑损伤定位和偏侧化、心脏自主神经支配异常、新的多态性及交感神经系统过度活跃的其他遗传原因在 NSC 中作用的研究数据。本文还讨论了围手术期处理应激相关性心肌病综合征的相关问题。未来的临床研究应探讨特定因素是否能解释不同患者对该疾病的不同易感性，并应致力于早期识别和分层高危患者，以便在重症监护和围手术期对这些患者进行更密切的监测和适当的管理。
